Research Associate King George's Medical University Lucknow, Uttar Pradesh, India
Abstract: Object : This study aims to investigate the circadian variability of blood pressure, sleep-activity rhythms, and metabolic hormone levels (thyroid, insulin, catecholamines) in metabolic disorder patients. It evaluates the potential impact of plant-based omega-3 (ALA, DHA) and palmitic acid supplementation on these parameters and their clinical implications for circadian and metabolic homeostasis. Methods : This ongoing study involves 200 participants aged 25–60 years, divided into four groups: healthy controls (n=50), Type 2 diabetes patients (n=50), obese individuals without diabetes or hypertension (n=50), and essential hypertension patients (n=50). Baseline assessments include 24-hour ambulatory blood pressure monitoring (ABPM) for blood pressure and heart rate variability, actigraphy and sleep questionnaires for sleep-activity rhythms, and biochemical profiling of metabolic hormones and lipid profiles. Participants receive a daily supplement of plant-based omega-3 and palmitic acid for 12 weeks, followed by reassessment of all parameters. Result : Initial findings suggest significant circadian disruptions in Type 2 diabetes patients, characterized by altered activity patterns and irregular blood pressure rhythms. Awareness of omega-3 fatty acids and their health benefits was alarmingly low among participants, with only 16% demonstrating any knowledge. This lack of awareness correlates with a negligible intake of omega-3-rich foods in the study population. Conclusion : This study provides novel insights into the interaction between circadian rhythms, metabolic disorders, and dietary fatty acids. Preliminary evidence supports the hypothesis that plant-based omega-3 supplementation can improve circadian rhythmicity and metabolic hormone regulation, offering a potential strategy for managing metabolic disorders. Further analyses will elucidate the broader clinical implications of these findings.
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