Abstract: Biosurfactant rhamnolipids are currently widely used as natural and effective ingredients in daily-care products which requires skin-friendliness. It is commonly accepted that chemically synthesized surfactants could cause itching or even corrosion. Hence, this research evaluation of the rhamnolipids on the anti-inflammation and anti-alergic activitities on RAW264.7, RBL-2H3 and HaCT cells. As found, rhamnolipid could inhibit LPS-induced morphological differentiation of cells, reactie oxygen species (ROS), TNF, cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) expression in RAW264.7. Rhamnolipid also inhibtied the expression of cytokines histamine and hexosaminidase that are known to induce infalmmation and allergicreponses in RBL-2H3 cells at exposure to LPS. Furthermore, rhamnolipid could suppress the inflammatory and allergic responses in HaCaT cells according to the expression of TNF and IL-31 while modulating transient receptor potential vanilloid 1 (TRPV1) ion channel activity. The results indicated the great value of rhamnolipids in modulating the immune-related inflammation as well as allergic reaction, showing superiority over chemical surfactants.
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